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Literature summary for 2.4.2.30 extracted from

  • Dhoonmoon, A.; Schleicher, E.M.; Clements, K.E.; Nicolae, C.M.; Moldovan, G.L.
    Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR (2020), Nucleic Acids Res., 48, 7252-7264 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.30

Inhibitors

Inhibitors Comment Organism Structure
olaparib
-
 Homo sapiens
rabusertib
-
 Homo sapiens
VE822
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor Homo sapiens
-
 nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
PA-TU-8988T cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?

Synonyms

Synonyms Comment Organism
ADP-ribosyltransferase
-
 Homo sapiens
ARTD8
-
 Homo sapiens
PARP14
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme PARP14 is an important modulator of the response to ATR-CHK1 pathway inhibitors Homo sapiens